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Precise Control of Cell Adhesion by Combination of Surface Chemistry and Soft Lithography
Author(s) -
Zheng Wenfu,
Zhang Wei,
Jiang Xingyu
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200104
Subject(s) - nanotechnology , cell adhesion , adhesion , biomaterial , soft lithography , microfabrication , extracellular matrix , materials science , lithography , tissue engineering , biological materials , chemistry , biomedical engineering , engineering , composite material , biochemistry , medicine , alternative medicine , optoelectronics , pathology , fabrication
The adhesion of cells on an extracellular matrix (ECM) (in vivo) or the surfaces of materials (in vitro) is a prerequisite for most cells to survive. The rapid growth of nano/microfabrication and biomaterial technologies has provided new materials with excellent surfaces with specific, desirable biological interactions with their surroundings. On one hand, the chemical and physical properties of material surfaces exert an extensive influence on cell adhesion, proliferation, migration, and differentiation. On the other hand, material surfaces are useful for fundamental cell biology research and tissue engineering. In this Review, an overview will be given of the chemical and physical properties of newly developed material surfaces and their biological effects, as well as soft lithographic techniques and their applications in cell biology research. Recent advances in the manipulation of cell adhesion by the combination of surface chemistry and soft lithography will also be highlighted.