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Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms
Author(s) -
Quigley Anita F.,
Razal Joselito M.,
Kita Magdalena,
Jalili Rohoullah,
Gelmi Amy,
Penington Anthony,
OvalleRobles Raquel,
Baughman Ray H.,
Clark Graeme M.,
Wallace Gordon G.,
Kapsa Robert M. I.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200102
Subject(s) - nanotopography , electrical conductor , polypyrrole , nanostructure , materials science , nanotechnology , stimulation , conductive polymer , polymer , neuroscience , biology , composite material , polymerization
In this study, nanostructured conductive platforms synthesized from aligned multiwalled carbon nanotubes and polypyrrole are investigated as myo‐regenerative scaffolds. Myotube formation follows a linear path on the platforms coinciding with extent of nanotopography. In addition, electrical stimulation enhances myo‐nuclear number and differentiation. These studies demonstrate that conductive polymer platforms can be used to influence muscle cell behaviour through nanostructure and electrical stimulation.