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Surface‐Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome‐Aided Delivery of Therapeutic Small Molecules
Author(s) -
HostaRigau Leticia,
Jensen Bettina E. B.,
Fjeldsø Kit S.,
Postma Almar,
Li Guoxin,
Goldie Kenneth N.,
Albericio Fernando,
Zelikin Alexander N.,
Städler Brigitte
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200092
Subject(s) - vinyl alcohol , polymersome , materials science , viability assay , self healing hydrogels , surface modification , drug delivery , composite number , coating , chemical engineering , nanotechnology , polymer chemistry , cell , chemistry , copolymer , polymer , composite material , biochemistry , amphiphile , engineering
The polymersome‐aided trapping of a small antitumor compound in a poly(vinyl alcohol) hydrogel matrix and the subsequent viability of myoblasts adhering to this coating is reported. The results reveal an enhanced reduction of the cell viability when the therapeutic compound is delivered from the surface in comparison to solution‐based delivery.