Regulating Specific Growth Factor Signaling Using Immobilized Branched Ligands | Zendy

Toepke Michael W. | Zendy; Impellitteri Nicholas A. | Zendy; Lan Levengood Sheeny K. | Zendy; Boeldt Derek S. | Zendy; Bird Ian M. | Zendy; Murphy William L. | Zendy

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Regulating Specific Growth Factor Signaling Using Immobilized Branched Ligands

Author(s) -

Toepke Michael W.,

Impellitteri Nicholas A.,

Lan Levengood Sheeny K.,

Boeldt Derek S.,

Bird Ian M.,

Murphy William L.

Publication year - 2012

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201200077

Subject(s) - vegf receptors , dimer , peptide , vascular endothelial growth factor , chemistry , microsphere , computer science , computational biology , combinatorial chemistry , nanotechnology , microbiology and biotechnology , biochemistry , materials science , biology , cancer research , chemical engineering , engineering , organic chemistry

VEGF‐binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF‐mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.

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