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Regulating Specific Growth Factor Signaling Using Immobilized Branched Ligands
Author(s) -
Toepke Michael W.,
Impellitteri Nicholas A.,
Lan Levengood Sheeny K.,
Boeldt Derek S.,
Bird Ian M.,
Murphy William L.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200077
Subject(s) - vegf receptors , dimer , peptide , vascular endothelial growth factor , chemistry , microsphere , computer science , computational biology , combinatorial chemistry , nanotechnology , microbiology and biotechnology , biochemistry , materials science , biology , cancer research , chemical engineering , engineering , organic chemistry
VEGF‐binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF‐mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.