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Anti‐cAngptl4 Ab‐Conjugated N‐TiO 2 /NaYF 4 :Yb,Tm Nanocomposite for Near Infrared‐Triggered Drug Release and Enhanced Targeted Cancer Cell Ablation
Author(s) -
Xu Qing Chi,
Zhang Yan,
Tan Ming Jie,
Liu Yang,
Yuan Shaojun,
Choong Cleo,
Tan Nguan Soon,
Tan Timothy Thatt Yang
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200055
Subject(s) - conjugated system , materials science , nanomedicine , nanocomposite , cancer cell , drug , drug delivery , photocatalysis , nanotechnology , nanoparticle , nuclear chemistry , cancer research , cancer , chemistry , medicine , organic chemistry , pharmacology , catalysis , polymer , composite material
Nanomedicine: NIR‐active N‐TiO 2 /NaYF 4 :Yb,Tm nanocomposites (NCs) were synthesized for the first time and its potential applications in drug release and targeted cancer cell ablation are explored. Upon 980 nm laser irradiation, the anti‐cAngptl4 Ab‐conjugated N‐TiO 2 /NaYF 4 :Yb,Tm NCs shows a significant increase in apoptotic A‐5RT3 cells when compared with that of the unconjugated NCs. The mechanisms for NIR‐induced photocatalysis, drug release and targeted cancer cell killing are proposed.