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Microfluidic Cell Sorter ( μ FCS) for On‐chip Capture and Analysis of Single Cells
Author(s) -
Chung Jaehoon,
Shao Huilin,
Reiner Thomas,
Issadore David,
Weissleder Ralph,
Lee Hakho
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200046
Subject(s) - general hospital , library science , medical school , medicine , computer science , family medicine , medical education
A low‐cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on‐chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor‐bearing mice.