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Stealth Rare Earth Oxide Nanodiscs for Magnetic Resonance Imaging
Author(s) -
Bailey Mark J.,
van der Weegen Rob,
Klemm Piper J.,
Baker Suzanne L.,
Helms Brett A.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200039
Subject(s) - ionic bonding , nanocrystal , rare earth , materials science , magnetic resonance imaging , nuclear magnetic resonance , oxide , nanotechnology , contrast (vision) , computer science , chemistry , physics , ion , organic chemistry , artificial intelligence , radiology , medicine , metallurgy
Configuring RE 2 O 3 nanocrystals with pseudo‐2D morphologies confers substantive gains in relaxivities over equivalent spherical counterparts. The most promising arises from Gd 2 O 3 whose ionic transverse and longitudinal relaxivities were as high as r 1 = 12.7 m M −1 s −1 and r 2 = 17.2 m M −1 s −1 (dispersed in H 2 O, T = 37 °C & B 0 = 1.41 T), pointing to new opportunities to achieve high contrast MRI while concomitantly affording longer half‐life potential in vivo.