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Latent TGF‐β Hydrogels for Cartilage Tissue Engineering
Author(s) -
Place Elsie S.,
Nair Rekha,
Chia Hele.,
Szulgit Greg,
Lim Erhhsuin,
Stevens Molly M.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200038
Subject(s) - self healing hydrogels , hyaluronic acid , transforming growth factor , chondrogenesis , scaffold , tissue engineering , cartilage , transforming growth factor beta , in vitro , articular cartilage , materials science , microbiology and biotechnology , tgf beta signaling pathway , biomedical engineering , chemistry , biology , biochemistry , anatomy , osteoarthritis , pathology , medicine , polymer chemistry , alternative medicine
A biomimetic delivery strategy for transforming growth factor beta (TGF‐β) is described , in which TGF‐β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.