Latent TGF‐β Hydrogels for Cartilage Tissue Engineering | Zendy

Place Elsie S. | Zendy; Nair Rekha | Zendy; Chia Hele. | Zendy; Szulgit Greg | Zendy; Lim Erhhsuin | Zendy; Stevens Molly M. | Zendy

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Latent TGF‐β Hydrogels for Cartilage Tissue Engineering

Author(s) -

Place Elsie S.,

Nair Rekha,

Chia Hele.,

Szulgit Greg,

Lim Erhhsuin,

Stevens Molly M.

Publication year - 2012

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201200038

Subject(s) - self healing hydrogels , hyaluronic acid , transforming growth factor , chondrogenesis , scaffold , tissue engineering , cartilage , transforming growth factor beta , in vitro , articular cartilage , materials science , microbiology and biotechnology , tgf beta signaling pathway , biomedical engineering , chemistry , biology , biochemistry , anatomy , osteoarthritis , pathology , medicine , polymer chemistry , alternative medicine

A biomimetic delivery strategy for transforming growth factor beta (TGF‐β) is described , in which TGF‐β is presented in a latent form (the small latent complex, SLC), which is inactive until modified by the actions of the cells. In this work, SLC is tethered to a hyaluronic acid hydrogel scaffold to enhance in vitro chondrogenesis.

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