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Hybrid BaYbF 5 Nanoparticles: Novel Binary Contrast Agent for High‐Resolution in Vivo X‐ray Computed Tomography Angiography
Author(s) -
Liu Yanlan,
Ai Kelong,
Liu Jianhua,
Yuan Qinghai,
He Yangyang,
Lu Lehui
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200028
Subject(s) - in vivo , contrast (vision) , nanoparticle , materials science , iodinated contrast , angiography , x ray , iohexol , biomedical engineering , radiology , computed tomography , medicine , nanotechnology , optics , physics , microbiology and biotechnology , biology , renal function
A novel CT contrast agent denoted as BaYbF 5 @SiO 2 @PEG is presented. The as‐prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X‐ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in‐vivo X‐ray CT angiography.