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Delivery of Ricin Toxin A‐Chain by Peptide‐Targeted Mesoporous Silica Nanoparticle‐Supported Lipid Bilayers
Author(s) -
Epler Katharine,
Padilla David,
Phillips Genevieve,
Crowder Peter,
Castillo Robert,
Wilkinson Dan,
Wilkinson Brian,
Burgard Cameron,
Kalinich Robin,
Townson Jason,
Chackerian Bryce,
Willman Cheryl,
Peabody David,
Wharton Walker,
Brinker C. Jeffrey,
Ashley Carlee,
Carnes Eric
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200022
Subject(s) - mesoporous silica , peptide , ricin , protocell , toxin , nanoparticle , nanotechnology , viability assay , biophysics , liposome , materials science , chemistry , cell , mesoporous material , biochemistry , biology , membrane , catalysis
Mesoporous silica nanoparticle‐supported lipid bilayers , or “protocells”, exhibit a high loading capacity, enhanced colloidal stability, and peptide‐directed, cell‐specific uptake, making them especially well‐suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A‐chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.