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Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering
Author(s) -
Skaat Hadas,
ZivPolat Ofra,
Shahar Abraham,
Last David,
Mardor Yael,
Margel Shlomo
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201100056
Subject(s) - maghemite , magnetic nanoparticles , nanoparticle , tissue engineering , conjugated system , nanotechnology , materials science , computer science , polymer , biomedical engineering , engineering , composite material
Novel magnetic fibrin hydrogel scaffolds for cell implantation and tissue engineering are reported. The magnetic scaffolds are produced by the interaction between thrombin‐conjugated maghemite nanoparticles of narrow size distribution and fibrinogen. These scaffolds, enriched with growth factor conjugated fluorescent maghemite nanoparticles, provide a supporting 3D environment for massive proliferation of various cell types, and can be successfully visualized by MRI.