Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted‐PEG‐Based Micelles for the Treatment of Glioblastoma | Zendy

Locatelli Erica | Zendy; Broggi Francesca | Zendy; Ponti Jessica | Zendy; Marmorato Patrick | Zendy; Franchini Fabio | Zendy; Lena Stefano | Zendy; Franchini Mauro Comes | Zendy

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Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted‐PEG‐Based Micelles for the Treatment of Glioblastoma

Author(s) -

Locatelli Erica,

Broggi Francesca,

Ponti Jessica,

Marmorato Patrick,

Franchini Fabio,

Lena Stefano,

Franchini Mauro Comes

Publication year - 2012

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201100047

Subject(s) - nanocarriers , peg ratio , micelle , nanoparticle , conjugated system , peptide , glioblastoma , cytotoxic t cell , cell culture , chemistry , biophysics , nanotechnology , materials science , combinatorial chemistry , in vitro , cancer research , biochemistry , polymer , medicine , organic chemistry , aqueous solution , biology , finance , economics , genetics

A simple method for the synthesis of lipophilic Ag NPs have been developed . The coated Ag NPs have been entrapped into a FDA‐approved and targetable PEG‐based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell‐specific recognition of the Ag‐1‐PNPs‐Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μ M ) has been found on glioblastoma cell lines.

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