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Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted‐PEG‐Based Micelles for the Treatment of Glioblastoma
Author(s) -
Locatelli Erica,
Broggi Francesca,
Ponti Jessica,
Marmorato Patrick,
Franchini Fabio,
Lena Stefano,
Franchini Mauro Comes
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201100047
Subject(s) - nanocarriers , peg ratio , micelle , nanoparticle , conjugated system , peptide , glioblastoma , cytotoxic t cell , cell culture , chemistry , biophysics , nanotechnology , materials science , combinatorial chemistry , in vitro , cancer research , biochemistry , polymer , medicine , organic chemistry , aqueous solution , biology , finance , economics , genetics
A simple method for the synthesis of lipophilic Ag NPs have been developed . The coated Ag NPs have been entrapped into a FDA‐approved and targetable PEG‐based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell‐specific recognition of the Ag‐1‐PNPs‐Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μ M ) has been found on glioblastoma cell lines.