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Cell‐Specific Intracellular Anticancer Drug Delivery from Mesoporous Silica Nanoparticles with pH Sensitivity
Author(s) -
Luo Zhong,
Cai Kaiyong,
Hu Yan,
Zhang Beilu,
Xu Dawei
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201100030
Subject(s) - drug delivery , mesoporous silica , nanoparticle , intracellular , nanotechnology , materials science , drug , mesoporous material , chemistry , pharmacology , medicine , biochemistry , catalysis
A nanoreservoir for efficient intracellular anticancer drug delivery based on mesoporous silica nanoparticles end‐capped with lactobionic acid–grafted bovine serum albumin is fabricated. It demonstrates great potential for both cell‐specific endocytosis and intracellular pH‐responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed.