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Anisotropic Collagen Fibrillogenesis Within Microfabricated Scaffolds: Implications For Biomimetic Tissue Engineering
Author(s) -
Jean Aurélie,
Engelmayr George C.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201100017
Subject(s) - fibrillogenesis , tissue engineering , scaffold , materials science , biophysics , biomedical engineering , nanotechnology , fibril , biology , medicine
Anisotropic collagen fibrillogenesis is demonstrated within the pores of an accordion‐like honeycomb poly(glycerol sebacate) tissue engineering scaffold. Confocal reflectance microscopy and image analysis demonstrate increased fibril distribution order, fibril density, and alignment in accordion‐like honeycomb pores compared with collagen gelled unconstrained. Finite element modeling predicts how collagen gel and scaffold mechanics couple in matching native heart muscle stiffness and anisotropy.