Premium
Magnetic Nanocomposite Sol–Gel Systems for Remote Controlled Drug Release
Author(s) -
Hawkins Ashley M.,
Bottom Chelsie E.,
Liang Zhi,
Puleo David A.,
Hilt J. Zach
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201100013
Subject(s) - materials science , drug delivery , copolymer , polymer , nanotechnology , chemical engineering , sol gel , nanocomposite , phase transition , phase (matter) , biomedical engineering , composite material , chemistry , organic chemistry , medicine , engineering , physics , quantum mechanics
The remote heating of iron oxide nanoparticles in an alternating magnetic field is used to drive a thermoresponsive sol‐gel block copolymer, Pluronic® F‐127, through the upper phase transition temperature. This phase change triggers an accelerated release rate of a model drug. Actuation and return to baseline levels are demonstrated for multiple AMF doses.