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Inosine‐Based Supramolecular Hydrogel for Highly Efficient PD‐L1 Blockade Therapy via Mediating CD8 + T Cells (Adv. Funct. Mater. 33/2022)
Author(s) -
Qi Jiajia,
Ding Tingting,
Liu Tiannan,
Xia Xin,
Wu Shihong,
Liu Jiang,
Chen Qianming,
Zhang Dunfang,
Zhao Hang
Publication year - 2022
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202270190
Subject(s) - inosine , materials science , self healing hydrogels , blockade , cd8 , in vivo , supramolecular chemistry , cytotoxic t cell , tumor microenvironment , cancer research , biophysics , nanotechnology , immune system , in vitro , chemistry , immunology , biochemistry , tumor cells , biology , receptor , crystal structure , polymer chemistry , crystallography , adenosine , microbiology and biotechnology
Tumor Immunotherapeutic Gels In article number 2204273, Dunfang Zhang, Hang Zhao, and co‐workers demonstrate that an inosine‐based supramolecular hydrogel, IPBisoG, can achieve the gradual and sequential release of inosine and aPDL1. Inosine, which enhancs the proliferation and function of CD8 + T cells, together with aPDL1, the blocker of the immunosuppressive pathway in the tumor microenvironment, could highly enhance the in vivo efficacy of PD‐L1 blockade therapy.