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Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu 2− x Se Nanoparticles to Enhance Anti‐Tumor Immunity (Adv. Funct. Mater. 12/2022)
Author(s) -
Zheng Yanhui,
Han Yaobao,
Wang Tingting,
Liu Hanghang,
Sun Qiao,
Hu Shijun,
Chen Jianquan,
Li Zhen
Publication year - 2022
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202270072
Subject(s) - reprogramming , phenotype , macrophage polarization , materials science , reactive oxygen species , tumor microenvironment , cancer research , nanoparticle , irf5 , immunity , microbiology and biotechnology , tumor progression , tumor cells , nanotechnology , immune system , innate immune system , biology , cell , immunology , biochemistry , cancer , genetics , interferon regulatory factors , gene
Reprogramming Tumor‐Associated Macrophages In article number 2108971, Zhen Li and co‐workers find that ultra‐small Cu 2− x Se nanoparticles can effectively polarize tumor‐associated macrophages (TAMs) from the tumor‐supportive M2 phenotype into anti‐tumor M1 phenotype to significantly boost anti‐tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS‐TRAF6‐IRF5‐IL‐23 signaling pathway, rather than the classic ROS‐NF‐?B‐iNOS pathway.