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Microneedle‐Based Local Delivery of CCL22 and IL‐2 Enriches T reg Homing to the Skin Allograft and Enables Temporal Monitoring of Immunotherapy Efficacy (Adv. Funct. Mater. 44/2021)
Author(s) -
Puigmal Núria,
Dosta Pere,
Solhjou Zhabiz,
Yatim Karim,
Ramírez Cynthia,
Choi John Y.,
Alhaddad Juliano B.,
Cosme Ana Paula,
Azzi Jamil,
Artzi Natalie
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170324
Subject(s) - immune system , homing (biology) , immunotherapy , materials science , medicine , cancer research , biomedical engineering , immunology , biology , ecology
Microneedle Arrays In article number 2100128, Jamil Azzi, Natalie Artzi, and co‐workers present a theranostic microneedle‐based platform for the simultaneous delivery of immune modulators and sampling of skin interstitial fluid to monitor the response to the therapy. Using a model of allogeneic skin transplant in mice, they show that the microneedle‐mediated delivery of the therapy can help regulate the immune system locally, without inducing systemic immune suppression, increasing the prospects of graft survival.