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Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors (Adv. Funct. Mater. 37/2021)
Author(s) -
Colombani Thibault,
Eggermont Loek J.,
Hatfield Stephen M.,
Rogers Zachary J.,
Rezaeeyazdi Mahboobeh,
Memic Adnan,
Sitkovsky Michail V.,
Bencherif Sidi A.
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170274
Subject(s) - immune system , infiltration (hvac) , cytotoxicity , materials science , oxygen , cancer research , immunosuppression , hypoxia (environmental) , tumor microenvironment , lymphocytic infiltration , nanotechnology , immunology , chemistry , medicine , biochemistry , composite material , in vitro , organic chemistry
Oxygen‐Generating Cryogels In article number 2102234, Sidi A. Bencherif and co‐workers use injectable oxygen‐generating cryogels (O 2 ‐cryogels) as a strategy to boost antitumor immune responses. These noninvasive biomaterials are designed to controllably release oxygen, reverse hypoxia‐driven immunosuppression, and promote the infiltration of pre‐existing immune‐fighting immune cells into tumors. O 2 ‐cryogels are a novel platform to deliver oxygen locally as a coadjuvant, reinforce tumor‐infiltrating T cells, and ultimately enhance cancer immunotherapies.