Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors (Adv. Funct. Mater. 37/2021) | Zendy

Colombani Thibault | Zendy; Eggermont Loek J. | Zendy; Hatfield Stephen M. | Zendy; Rogers Zachary J. | Zendy; Rezaeeyazdi Mahboobeh | Zendy; Memic Adnan | Zendy; Sitkovsky Michail V. | Zendy; Bencherif Sidi A. | Zendy

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Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors (Adv. Funct. Mater. 37/2021)

Author(s) -

Colombani Thibault,

Eggermont Loek J.,

Hatfield Stephen M.,

Rogers Zachary J.,

Rezaeeyazdi Mahboobeh,

Memic Adnan,

Sitkovsky Michail V.,

Bencherif Sidi A.

Publication year - 2021

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.202170274

Subject(s) - immune system , infiltration (hvac) , cytotoxicity , materials science , oxygen , cancer research , immunosuppression , hypoxia (environmental) , tumor microenvironment , lymphocytic infiltration , nanotechnology , immunology , chemistry , medicine , biochemistry , composite material , in vitro , organic chemistry

Oxygen‐Generating Cryogels In article number 2102234, Sidi A. Bencherif and co‐workers use injectable oxygen‐generating cryogels (O 2 ‐cryogels) as a strategy to boost antitumor immune responses. These noninvasive biomaterials are designed to controllably release oxygen, reverse hypoxia‐driven immunosuppression, and promote the infiltration of pre‐existing immune‐fighting immune cells into tumors. O 2 ‐cryogels are a novel platform to deliver oxygen locally as a coadjuvant, reinforce tumor‐infiltrating T cells, and ultimately enhance cancer immunotherapies.

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