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Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage (Adv. Funct. Mater. 33/2021)
Author(s) -
Fu Wei,
Ma Lu,
Ju Yan,
Xu Jianguo,
Li Hao,
Shi Sirong,
Zhang Tao,
Zhou Ronghui,
Zhu Jianwei,
Xu Ruxiang,
You Chao,
Lin Yunfeng
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170239
Subject(s) - materials science , tetrahedron , dna , hematoma , nanotechnology , medicine , radiology , biology , crystallography , biochemistry , chemistry
Tetrahedral Framework DNA In article number 2101435, Chao You, Yunfeng Lin, and co‐workers design a nanomaterial (tetrahedron framework nucleic acid, tFNA) to carry siCCR2 that could promote hematoma absorption by regulating microglia polarization from the M1 toward M2 subtype during the acute phase of intracranial hemorrhage. The tFNA‐siCCR2 provide a novel therapeutic strategy for protecting neurological function in intracranial hemorrhage.