z-logo
Premium
Synergistic Chemotherapy: Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy (Adv. Funct. Mater. 29/2021)
Author(s) -
Wang Zhuoran,
Zhang Shuai,
Zhang Ruofei,
Chen Xuehui,
Sun Guoming,
Zhou Meng,
Han Qiubai,
Zhang Baoli,
Zhao Yue,
Jiang Bing,
Yang Yili,
Yan Xiyun,
Fan Kelong
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170207
Subject(s) - nanocarriers , nanocages , materials science , drug , drug delivery , amphiphile , nanotechnology , targeted drug delivery , pharmacology , cancer research , chemistry , polymer , medicine , biochemistry , copolymer , catalysis , composite material
In article number 2102004, Xiyun Yan, Kelong Fan, and co‐workers present an amphiphilic multi‐drug loading protein nanocage (Am‐PNCage) with a dual‐tumor targeting (CD71 and Integrin) property, which exhibits a spatiotemporally programmed cascade drug release pattern and kills drug‐resistant tumor cells synergistically. It represents a novel promising protein cage nanocarrier platform for co‐loading synergistic hydrophilic and hydrophobic drug pairs and targeted combination chemotherapy.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here