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Tumor Microenvironment Remodeling: Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling (Adv. Funct. Mater. 25/2021)
Author(s) -
Liu Haijun,
Wang Junfeng,
Wang Mingming,
Wang Yuzhen,
Shi Shanshan,
Hu Xiangxiang,
Zhang Quanguang,
Fan Daping,
Xu Peisheng
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170183
Subject(s) - tumor microenvironment , cancer research , metastasis , breast cancer , doxorubicin , cancer associated fibroblasts , nanomedicine , cancer , primary tumor , transdifferentiation , materials science , medicine , chemotherapy , tumor cells , biology , microbiology and biotechnology , nanotechnology , nanoparticle , stem cell
In article number 2100262, Peisheng Xu and co‐workers develop a homologous targeted cerium oxide nanoparticle system (T‐CeNP) remodeling the tumor microenvironment through inhibiting cancer‐associated fibroblast transdifferentiation and reprogramming it back to normal fibroblasts. T‐CeNP coupled with doxorubicin reduces the size of the primary tumor and prevents post‐surgery lung metastasis and liver metastasis of cancer in an orthotopic breast cancer model.