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Nanoprobe Design: Integrated Fluorescent Nanoprobe Design for High‐Speed In Vivo Two‐Photon Microscopic Imaging of Deep‐Brain Vasculature in Mice (Adv. Funct. Mater. 20/2021)
Author(s) -
Takezaki Minami,
Kawakami Ryosuke,
Onishi Shozo,
Suzuki Yasutaka,
Kawamata Jun,
Imamura Takeshi,
Hadano Shingo,
Watanabe Shigeru,
Niko Yosuke
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170138
Subject(s) - nanoprobe , materials science , fluorescence , two photon excitation microscopy , sapphire , optoelectronics , biomedical engineering , frame rate , laser , nanotechnology , optics , medicine , physics , nanoparticle
In article number 2010698, Yosuke Niko and co‐workers report a novel dye‐loaded nanoemulsion for high‐speed two‐photon microscopic imaging of the deep‐brain vasculature in mice. The nanoprobe fully exploits the performance of a Ti:sapphire laser and a gallium arsenide phosphide detector, allowing the visualization of hippocampal blood flow in mice at a high frame rate of 120 fps.