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Nanovectors: Mesenchymal Stromal Cell‐Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti‐Inflammatory Response (Adv. Funct. Mater. 3/2021)
Author(s) -
Martinez Jonathan O.,
Evangelopoulos Michael,
Brozovich Ava A.,
Bauza Guillermo,
Molinaro Roberto,
Corbo Claudia,
Liu Xuewu,
Taraballi Francesca,
Tasciotti Ennio
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202170019
Subject(s) - mesenchymal stem cell , inflammation , stromal cell , systemic administration , systemic inflammation , drug delivery , materials science , cancer research , medicine , immunology , nanotechnology , biology , pathology , in vivo , microbiology and biotechnology
In article number 2002997, Jonathan O. Martinez, Francesca Taraballi, and co‐workers present a new drug delivery approach, combining mesenchymal stromal cell (MSC) tropism with multistage nano‐vector (MSV) payload delivery. The MSCs act as a “trojan horse,” carrying MSV at the site of inflammation in an efficient manner. The system can transport anti‐inflammatory payloads, conserving local inflammatory targeting and rapidly triggering a reduction of local inflammation, extending survival to 100% in a lethal model of systemic inflammation.