Nanovectors: Mesenchymal Stromal Cell‐Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti‐Inflammatory Response (Adv. Funct. Mater. 3/2021) | Zendy

Martinez Jonathan O. | Zendy; Evangelopoulos Michael | Zendy; Brozovich Ava A. | Zendy; Bauza Guillermo | Zendy; Molinaro Roberto | Zendy; Corbo Claudia | Zendy; Liu Xuewu | Zendy; Taraballi Francesca | Zendy; Tasciotti Ennio | Zendy

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Nanovectors: Mesenchymal Stromal Cell‐Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti‐Inflammatory Response (Adv. Funct. Mater. 3/2021)

Author(s) -

Martinez Jonathan O.,

Evangelopoulos Michael,

Brozovich Ava A.,

Bauza Guillermo,

Molinaro Roberto,

Corbo Claudia,

Liu Xuewu,

Taraballi Francesca,

Tasciotti Ennio

Publication year - 2021

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.202170019

Subject(s) - mesenchymal stem cell , inflammation , stromal cell , systemic administration , systemic inflammation , drug delivery , materials science , cancer research , medicine , immunology , nanotechnology , biology , pathology , in vivo , microbiology and biotechnology

In article number 2002997, Jonathan O. Martinez, Francesca Taraballi, and co‐workers present a new drug delivery approach, combining mesenchymal stromal cell (MSC) tropism with multistage nano‐vector (MSV) payload delivery. The MSCs act as a “trojan horse,” carrying MSV at the site of inflammation in an efficient manner. The system can transport anti‐inflammatory payloads, conserving local inflammatory targeting and rapidly triggering a reduction of local inflammation, extending survival to 100% in a lethal model of systemic inflammation.

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