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Magnetic Helical Hydrogel Motor for Directing T Cell Chemotaxis
Author(s) -
Wang Zhen,
Fu Dongmei,
Xie Dazhi,
Fu Shaoming,
Wu Juanyan,
Wang Shuanghu,
Wang Fei,
Ye Yicheng,
Tu Yingfeng,
Peng Fei
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202101648
Subject(s) - materials science , nanotechnology , vinyl alcohol , superparamagnetism , chemotaxis , nanobiotechnology , magnetic field , nanoparticle , composite material , chemistry , physics , magnetization , receptor , quantum mechanics , polymer , biochemistry
Micro/nanomotors are attracting booming research enthusiasm with their revolutionary potential in biomedicine, sensing, and nanoengineering. Among the motors proposed, magnetic micro/nanomotors are of great interest with their high controllability and field biocompatibility. Yet the fabrication of magnetic actuated especially helical motors requires expensive and complicated instruments, 3D printing or glancing angle deposition, etc. Here, a soft and biocompatible helical poly(vinyl alcohol) (PVA) hydrogel motor via a versatile set‐up is engineered. The obtained helical hydrogel motor offers high capacity for chemokine CXCL12 and superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticles, which can then allow magnetic manipulation. With a low strength rotating magnetic field, the system is able to perform 3D precision navigation, necessary to steer the robotic system to a model diseased area. The chemokine cues from the hydrogel motor, acting as the synthetic leader cell, then directs immune T cell chemotactic migration. In a previously reported cell manipulating motor system, towing or pushing a single/two cell was demonstrated, with limited efficiency. This motor platform represents a novel approach for directing endogenous cell chemotaxis and organizing immune response.