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Poly(ionic liquid)/Ce‐Based Antimicrobial Nanofibrous Membrane for Blocking Drug‐Resistance Dissemination from MRSA‐Infected Wounds
Author(s) -
Luo Zhenhong,
Cui Hengqing,
Guo Jiangna,
Yao Jieran,
Fang Xia,
Yan Feng,
Wang Bin,
Mao Hailei
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202100336
Subject(s) - antimicrobial , microbiology and biotechnology , staphylococcus aureus , bacteria , kanamycin , methicillin resistant staphylococcus aureus , multiple drug resistance , drug resistance , escherichia coli , membrane , materials science , biology , antibiotics , gene , biochemistry , genetics
Resistant bacteria have become a global threat. Even if bacteria are killed, their carried drug‐resistant genes can remain in the environment and spread to other microbes via horizontal gene transfer. Development of antimicrobial materials with intrinsic gene break down activity can prevent the dissemination of released drug‐resistant genes from the dead bacteria. Herein, imidazolium type poly(ionic liquid) (PIL)/cerium (IV) ion‐based electrospun nanofibrous membranes (PIL‐Ce) are synthesized. The effects of PIL and Ce moieties on the antimicrobial properties against Gram‐negative Escherichia coli and kanamycin‐resistant E. coli , and Gram‐positive Staphylococcus aureus and methicillin‐resistant S. aureus (MRSA), as well as deoxyribonuclease‐mimic activities to the drug‐resistant genes of Kan R ( E. coli ) and mecA (MRSA) are investigated. The Ce‐containing PIL membranes show the high efficiencies to eradicate bacteria and disintegrate drug‐resistant genes. A wound treatment test using MRSA infected mice as the model further demonstrate that PIL‐Ce membranes combine both antibacterial and DNase‐mimic properties, and may have the potential application as a new “green” wound dressing to block the drug resistance spread in a clinical setting.