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NIR Laser‐Triggered Microneedle‐Based Liquid Band‐Aid for Wound Care
Author(s) -
Sun Yun,
Liu Jingling,
Wang Hongyu,
Li Shanshan,
Pan Xueting,
Xu Bolong,
Yang Hailong,
Wu Qingyuan,
Li Wenxuan,
Su Xin,
Huang Zhijun,
Guo Xindong,
Liu Huiyu
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202100218
Subject(s) - materials science , transdermal , hydrogen peroxide , nanotechnology , wound care , laser , biomedical engineering , pharmacology , optics , intensive care medicine , organic chemistry , medicine , chemistry , physics
Microneedles (MNs) have attracted widespread scientific and industrial interest in the past decade as an efficient, painless, low‐cost, and relatively safe transdermal drug delivery device. However, their drawbacks such as insufficient dose accuracy and limited penetration depth may limit the clinical applications. Here, a light‐controlled liquid band‐aid based on MNs is developed for antibacterial applications. Metal–organic framework‐derived peroxidase‐like nanozyme loaded in MNs can not only convert light energy into heat to enhance drug permeation but also decompose hydrogen peroxide into hydroxyl radicals for antibacteria. The heat generated by the nanozyme can facilitate MNs to melt and form a liquid band‐aid, which is beneficial to insulate the wound from the surrounding bacterial environment. These studies in a Staphylococcus aureus ‐infected mice model also prove that this laser‐triggered liquid band‐aid can efficiently reduce skin inflammation and promote wound healing. Together, these results demonstrate that the rational design of MNs can enhance antibacterial and wound healing efficiency.