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Hemostatic Elastin‐like Polypeptides: Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots (Adv. Funct. Mater. 51/2020)
Author(s) -
Urosev Ivan,
Lopez Morales Joanan,
Nash Michael A.
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070335
Subject(s) - elastin , fibrin , materials science , polymer , biophysics , polymer chemistry , composite material , medicine , biology , pathology , immunology
In article number 2005245, Michael A. Nash, Ivan Urosev, and Joanan Lopez Morales present new designs of intrinsically disordered proteins that specifically bind blood clots and modulate their biophysical properties. These hemostatic elastin‐like polypeptide polymers mechanically stiffen blood clots through a mechanism that is dependent on phase separation, resulting in the formation of strong clots with smaller pore sizes that staunch fluid flow and resist enzymatic degradation significantly more than natural clots, holding promise in the treatment of bleeding disorders and perioperative bleeding.