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Sarcoma‐Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies (Adv. Funct. Mater. 49/2020)
Author(s) -
Dong Jiantong,
Zhang Ryan Y.,
Sun Na,
Hu Junhui,
Smalley Matthew D.,
Zhou Anqi,
Hua Yue,
Rothermich Winston,
Chen Mengxiang,
Chen Jiayuan,
Ye Jinglei,
Teng PaiChi,
Qi Dongping,
Toretsky Jeffrey A.,
Tomlinson James S.,
Li Mengyuan,
Weiss Paul S.,
Jonas Steven J.,
Federman Noah,
Wu Lily,
Zhao Meiping,
Tseng HsianRong,
Zhu Yazhen
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070322
Subject(s) - extracellular vesicles , extracellular , covalent bond , vesicle , materials science , nanostructure , nanotechnology , intracellular , coupling (piping) , biophysics , microbiology and biotechnology , chemistry , membrane , biology , biochemistry , organic chemistry , metallurgy
In article number 2003237, Meiping Zhao, Hsian‐Rong Tseng, Yazhen Zhu, and co‐workers present a device for the purification of Ewing sarcoma‐derived extracellular vesicles (EVs) by coupling LINGO‐1 antibodies with the covalent chemistry‐mediated EV capture/release mechanism using a nanostructure‐embedded microchip. The purified EVs can be internalized by recipient cells to transfer the mRNA cargoes, highlighting the role of EVs as biological shuttles in intercellular communication.