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Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020)
Author(s) -
Ling Lu,
Mulligan Jeffrey A.,
Ouyang Yunxin,
Shimpi Adrian A.,
Williams Rebecca M.,
Beeghly Garrett F.,
Hopkins Benjamin D.,
Spector Jason A.,
Adie Steven G.,
Fischbach Claudia
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070320
Subject(s) - extracellular matrix , stromal cell , adipose tissue , cancer research , tumor microenvironment , breast cancer , microbiology and biotechnology , cancer , pathology , materials science , medicine , biology , tumor cells
In article number 1910650, Claudia Fischbach and co‐workers combine collagen‐embedded multicellular spheroids and advanced imaging to investigate the effect of adipose stromal cells (ASCs) on tumor cell invasion as a function of obesity. Obese ASCs increase collective tumor cell migration relative to lean ASCs by stimulating proteolytic and contractility‐dependent collagen remode ling, providing insights into how obesity promotes breast cancer malignancy.