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Tissue Engineering: Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers (Adv. Funct. Mater. 48/2020)
Author(s) -
Chen Amanda X.,
Chhabra Arnav,
Song HyunHo Greco,
Fleming Heather E.,
Chen Christopher S.,
Bhatia Sangeeta N.
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070317
Subject(s) - multicellular organism , tissue engineering , stromal cell , microbiology and biotechnology , apoptosis , nanotechnology , organoid , materials science , organogenesis , biology , biomedical engineering , cell , cancer research , engineering , biochemistry , gene
Tools are limited in resolving the dynamic contributions of multicellular interactions in bioengineered tissues. In article number 1910442, Sangeeta N. Bhatia and co‐workers present CAMEO (controlled apoptosis in multicellular tissues for engineering organogenesis) as a strategy to precisely manipulate and study tissue composition. Herein, organoids comprised of hepatocytes (red) and fibroblasts (green) are used to glean new insights into 3D tissue biology.