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Islet Transplantation: A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation (Adv. Funct. Mater. 15/2020)
Author(s) -
Razavi Mehdi,
Primavera Rosita,
Kevadiya Bhavesh D.,
Wang Jing,
Buchwald Peter,
Thakor Avnesh S.
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070099
Subject(s) - islet , transplantation , materials science , biomedical engineering , oxygen , pancreatic islets , matrix (chemical analysis) , biophysics , microbiology and biotechnology , medicine , chemistry , surgery , biology , composite material , insulin , organic chemistry
In article number 1902463, Avnesh S. Thakor and co‐workers design a macroporous collagen‐based cryogel bioscaffold that can accommodate transplanted pancreatic islets. Calcium peroxide, which generates a steady supply of oxygen, is then incorporated into the matrix of this bioscaffold. This clinically translatable platform improves the function and viability of transplanted islets until they can establish a new blood supply, and hence their own source of oxygen, following transplantation.