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Silica Nanodepletors: Silica Nanodepletors: Targeting and Clearing Alzheimer's β‐Amyloid Plaques (Adv. Funct. Mater. 15/2020)
Author(s) -
Jung Huijin,
Chung You Jung,
Wilton Rosemarie,
Lee Chang Heon,
Lee Byung Il,
Lim Jinyeong,
Lee Hyojin,
Choi JongHo,
Kang Hyuno,
Lee Byeongdu,
Rozhkova Elena A.,
Park Chan Beum,
Lee Joonseok
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070094
Subject(s) - materials science , cytotoxicity , in vivo , amyloid (mycology) , clearing , monomer , nanotechnology , mesoporous silica , ethylene glycol , biophysics , mesoporous material , medicine , in vitro , chemistry , biochemistry , pathology , biology , organic chemistry , finance , economics , catalysis , microbiology and biotechnology , composite material , polymer
In article number 1910475, Elena A. Rozhkova, Chan Beum Park, Joonseok Lee, and co‐workers design Aβ nanodepletors constructed from ultralarge mesoporous silica nanostructures and anti‐Aβ single chain variable fragments, which effectively capture monomeric Aβ peptides, inhibit Aβ aggregate formation, and attenuate Aβ‐mediated cytotoxicity. The Aβ‐targeting and clearing capabilities of the Aβ nanodepletors allow drastic reduction of the number of Aβ plaques in vivo, presenting high therapeutic potential towards Alzheimer's disease treatments.