Premium
Mechanotransduction: Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response (Adv. Funct. Mater. 3/2020)
Author(s) -
Kim Jeong In,
Hwang Tae In,
Lee Jeong Chan,
Park Chan Hee,
Kim Cheol Sang
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202070013
Subject(s) - mechanotransduction , materials science , piezoelectricity , biological neural network , cell fate determination , nanotechnology , topology (electrical circuits) , neuroscience , microbiology and biotechnology , biophysics , chemistry , transcription factor , biology , electrical engineering , biochemistry , gene , composite material , engineering
In article number 1907330, Chan Hee Park, Cheol Sang Kim, and co‐workers develop tunable topography modulated piezoelectric fibrous scaffolds that can regulate electrical cues and mechanotransduction to predict neural cell response. YAP translocation in cells provide clues to how cells respond to topological gradient structure‐modulated piezoelectric scaffolds. Such pleiotropic regulations could fine‐tune the YAP transcriptional pathway, allowing for the determination of cell fate including neural differentiation.