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Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion
Author(s) -
Zhang Ershuai,
Yang Jianhai,
Wang Ke,
Song Boyi,
Zhu Hui,
Han Xiangfei,
Shi Yuanjie,
Yang Chengbiao,
Zeng Zhipeng,
Cao Zhiqiang
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202009431
Subject(s) - adhesion , materials science , self healing hydrogels , tissue adhesion , curing (chemistry) , hemostasis , nanotechnology , biomedical engineering , surgery , medicine , composite material , polymer chemistry
Postoperative peritoneal adhesions are frequent complications for almost any type of abdominal and pelvic surgery. This leads to numerous medical problems and a huge financial burden to the patients. Current anti‐adhesion strategies focus mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to a certain level and their applying processes are far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an ideal anti‐adhesion material, including unique injectable yet malleable and self‐supporting properties, which enables an instant topical application, no curing, waiting, or suturing, no hemostasis requirement, protein/cell resistance, and biodegradability. The cream gel shows a major advancement in anti‐adhesion efficacy by completely and reliably preventing a primary and more severe recurrent adhesion in rat models.