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Effective Eradication of Tumors by Enhancing Photoacoustic‐Imaging‐Guided Combined Photothermal Therapy and Ultrasonic Therapy
Author(s) -
Xu Caina,
Wang Yanbing,
Wang Erlei,
Yan Nan,
Sheng Shu,
Chen Jie,
Lin Lin,
Guo Zhaopie,
Tian Huayu,
Chen Xuesi
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202009314
Subject(s) - photothermal therapy , materials science , nanorod , polyethylene glycol , sonication , in vivo , nanoparticle , photoacoustic imaging in biomedicine , nanotechnology , biomedical engineering , chemical engineering , optics , medicine , physics , microbiology and biotechnology , engineering , biology
Exploiting a comprehensive strategy that processes diagnosis and therapeutic functions is desired for eradicating tumors. In this study, two versatile nanoparticles are introduced: one is polyethylene glycol‐ and polyethyleneimine‐modified gold nanorods (mPEG–PEI–AuNRs), and the other is formed by electrostatic interactions between mPEG–PEI and calcium carbonate nanoparticles (mPEG–PEI/CaNPs). These two nanoparticles possess following favorable properties: 1) mPEG–PEI–AuNRs and mPEG–PEI/CaNPs show not only high cell uptake in acidic tumoral pH, but also efficient accumulation in tumors with prolonged circulation. 2) mPEG–PEI/CaNPs can generate carbon dioxide (CO 2 ) bubbles in acidic tumoral environment and the photoacoustic (PA) signals from mPEG–PEI–AuNRs can be enhanced with the generation of CO 2 bubbles. 3) The tumors can be eradicated by combining photothermal therapy (PTT) with ultrasonic therapy (UST) under the near‐infrared (NIR) laser and ultrasonic irradiation with the presence of mPEG–PEI–AuNRs and CO 2 bubbles from mPEG–PEI/CaNPs. The detailed evaluation of cellular uptake, photothermal property of mPEG–PEI–AuNRs, CO 2 bubbles’ generation from mPEG–PEI/CaNPs, imaging, and combined PTT and UST are carried out in vitro or in vivo. This work has great potential usage for diagnosis and treatment in the future.