Premium
Remote Switching of Elastic Movement of Decorated Ligand Nanostructures Controls the Adhesion‐Regulated Polarization of Host Macrophages
Author(s) -
Thangam Ramar,
Kim Myeong Soo,
Bae Gunhyu,
Kim Yuri,
Kang Nayeon,
Lee Sungkyu,
Jung Hee Joon,
Jang Jinhyeok,
Choi Hyojun,
Li Na,
Kim Minjin,
Park Sangwoo,
Kim Seong Yeol,
Koo Thomas Myeongseok,
Fu Hong En,
Jeon Yoo Sang,
AmbriovićRistov Andreja,
Song JaeJun,
Kim Soo Young,
Park Steve,
Wei Qiang,
Ko Changhyun,
Lee KiBum,
Paulmurugan Ramasamy,
Kim Young Keun,
Kang Heemin
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202008698
Subject(s) - materials science , ligand (biochemistry) , linker , polarization (electrochemistry) , colloidal gold , adhesion , nanostructure , nanoparticle , biophysics , nanotechnology , macrophage polarization , in vitro , receptor , chemistry , macrophage , composite material , biology , biochemistry , computer science , operating system
Design of materials with remote switchability of the movement of decorated nanostructures presenting cell‐adhesive Arg‐Gly‐Asp ligand can decipher dynamic cell‐material interactions in decorated ligand nanostructures. In this study, the decoration of ligand‐bearing gold nanoparticles (ligand‐AuNPs) on the magnetic nanoparticle (MNP) with varying ligand‐AuNP densities is demonstrated, which are flexibly coupled to substrate in various MNP densities to maintain constant macroscopic ligand density. Magnetic switching of upward (“Upper Mag”) or downward (“Lower Mag”) movement of varying ligand‐AuNPs is shown via stretching and compression of the elastic linker, respectively. High ligand‐AuNP densities promote macrophage adhesion‐regulated M2 polarization that inhibits M1 polarization. Remote switching of downward movement (“Lower Mag”) of ligand‐AuNPs facilitates macrophage adhesion‐regulated M2 polarization, which is conversely suppressed by their upward movement (“Upper Mag”), both in vitro and in vivo. These findings are consistent with human primary macrophages. These results provide fundamental understanding into designing materials with decorated nanostructures in both high ligand‐AuNP density and downward movement of the ligand‐AuNPs toward the substrate to stimulate adhesion‐regulated M2 polarization of macrophages while suppressing pro‐inflammatory M1 polarization, thereby facilitating tissue‐healing responses.