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Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery
Author(s) -
Zhou Lei,
Dai Cong,
Fan Lei,
Jiang Yuhe,
Liu Can,
Zhou Zhengnan,
Guan Pengfei,
Tian Yu,
Xing Jun,
Li Xiaojun,
Luo Yian,
Yu Peng,
Ning Chengyun,
Tan Guoxin
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202007457
Subject(s) - adhesive , materials science , self healing hydrogels , tissue adhesion , adhesion , sealant , biocompatible material , biomedical engineering , biopolymer , extracellular matrix , wound healing , methacrylate , polymer , nanotechnology , surgery , composite material , polymerization , polymer chemistry , chemistry , layer (electronics) , medicine , biochemistry
Abstract Biocompatible hydrogel adhesives with multifunctional properties, including injectability, fast self‐healing, and suitable on‐demand detachment, are highly desired for minimally invasive procedures, but such materials are still lacking. Herein, an injectable self‐healing biocompatible hydrogel adhesive with thermoresponsive reversible adhesion based on two extracellular matrix‐derived biopolymers, gelatin and chondroitin sulfate, is developed to be used as a surgical adhesive for sealing or reconnecting ruptured tissues. The resulting hydrogels present good self‐healing and can be conveniently injected through needles. The strong tissue adhesion at physiological temperatures originates from the Schiff base and hydrogen bonding interactions between the hydrogel and tissue that can be weakened at low temperatures, thereby easily detaching the hydrogel from the tissue in the gelation state. In vivo and ex vivo rat model show that the adhesives can effectively seal bleeding wounds and fluid leakages in the absence of sutures or staples. Specifically, a proof of concept experiment in a damaged rat liver model demonstrates the ability of the adhesives to act as a suitable laparoscopic sealant for laparoscopic surgery. Overall, the adhesive has several advantages, including low cost and ease of production and application that make it an exceptional multifunctional tissue adhesive/sealant, effective in minimally invasive surgical applications.