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Strategies for Delivering Nanoparticles across Tumor Blood Vessels
Author(s) -
Sheth Vinit,
Wang Lin,
Bhattacharya Resham,
Mukherjee Priyabrata,
Wilhelm Stefan
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202007363
Subject(s) - nanoparticle , paracellular transport , materials science , transcellular , nanotechnology , nanomedicine , drug delivery , tumor microenvironment , tumor cells , cancer research , biophysics , medicine , biology , membrane , permeability (electromagnetism) , genetics
Abstract Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery process are not fully understood. Here, the biological and physical characteristics of the tumor vasculature and the tumor microenvironment are explored and how these features affect nanoparticle transport across tumor blood vessels is discussed. The biological and physical methods to deliver nanoparticles into tumors are reviewed and paracellular and transcellular nanoparticle transport pathways are explored. Understanding the underlying pathways and mechanisms of nanoparticle tumor delivery will inform the engineering of safer and more effective nanomedicines for clinical translation.