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NIR Light‐Driven Bi 2 Se 3 ‐Based Nanoreactor with “Three in One” Hemin‐Assisted Cascade Catalysis for Synergetic Cancer Therapy
Author(s) -
Niu Xiaoyan,
Liu Yang,
Li Xiaomin,
Wang Wei,
Yuan Zhi
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202006883
Subject(s) - nanoreactor , hemin , catalysis , materials science , porphyrin , photochemistry , reactive oxygen species , nanoparticle , photocatalysis , combinatorial chemistry , nanotechnology , chemistry , heme , organic chemistry , biochemistry , enzyme
Photocatalytic semiconductor‐based nanoreactors, that convert nontoxic molecules into toxic ones for cancer therapy, have attracted great interest. However, its therapeutic efficiency is limited by the fast electron–hole recombination within a narrow bandgap, low oxidative damage of H 2 O 2 , and tumor hypoxia. Herein, aggregation‐limited hemin is introduced onto Bi 2 Se 3 nanoparticles for successively solving these problems. The nanoreactor (Bi 2 Se 3 @hemin‐(G‐H)‐HA NPs) is obtained through adamantane modified hemin and β‐cyclodextrin modified hyaluronic acid complexing and wrapping on Bi 2 Se 3 NPs via host–guest and electrostatic interaction. Once irradiated by NIR light, the hemin assists Bi 2 Se 3 to separate electron–hole pairs and catalyze endogenous H 2 O to generate vast H 2 O 2 , resulting in a 3.9‐fold higher H 2 O 2 generation than that of individual Bi 2 Se 3 . Subsequently, H 2 O 2 is catalyzed by aggregation‐limited hemin to generate highly toxic •OH and •O 2 − , which improves the total reactive oxygen species generation of Bi 2 Se 3 @hemin‐(G‐H)‐HA by 10.8‐fold compared to that of Bi 2 Se 3 NPs. Importantly, the cytotoxicity result exhibits a death rate of HepG2 cells of above 90%, even though in a simulated hypoxic environment. Additionally, the in vivo result indicates this nanoreactor realizes an synergetic anticancer effect with a tumor inhibition rate of 92.3%. Overall, such a nanoreactor with hemin‐assisted cascade catalysis is a promising candidate for improving therapeutic efficacy.