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A Wearable Optical Microfibrous Biomaterial with Encapsulated Nanosensors Enables Wireless Monitoring of Oxidative Stress
Author(s) -
Safaee Mohammad Moein,
Gravely Mitchell,
Roxbury Daniel
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202006254
Subject(s) - nanosensor , materials science , carbon nanotube , wearable computer , nanotechnology , analyte , fluorescence , hydrogen peroxide , biomaterial , microfluidics , biosensor , biomedical engineering , optoelectronics , computer science , optics , chemistry , embedded system , physics , organic chemistry , medicine
In an effort to facilitate personalized medical approaches, the continuous and noninvasive monitoring of biochemical information using wearable technologies can enable a detailed understanding of an individual's physiology. Reactive oxygen species (ROS) are a class of oxygen‐containing free radicals that function in a wide range of biological processes. In wound healing applications, the continuous monitoring of ROS through a wearable diagnostics platform is essential for the prevention of chronicity and pathogenic infection. Here, a versatile one‐step procedure is utilized to fabricate optical core‐shell microfibrous textiles incorporating single‐walled carbon nanotubes (SWCNTs) for the real‐time optical monitoring of hydrogen peroxide concentrations in in vitro wounds. The environmentally sensitive and non‐photobleachable fluorescence of SWCNTs enables continuous analyte monitoring without decay in signal over time. The existence of multiple chiralities of SWCNTs emitting near‐infrared fluorescence with narrow bandwidths allows a ratiometric signal readout invariant to the excitation source distance and exposure time. The individual fibers encapsulate the SWCNT nanosensors for at least 21 days without apparent loss in structural integrity. Moreover, the microfibrous textiles are utilized to spatially resolve peroxide concentrations using a camera and further integrated into commercial wound bandages without significant degradation in their optical properties.