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Mimic Drug Dosage Modulation for Neuroplasticity Based on Charge‐Trap Layered Electronics
Author(s) -
Gao Caifang,
Lee MuPai,
Li Mengjiao,
Lee KoChun,
Yang FengShou,
Lin CheYi,
Watanabe Kenji,
Taniguchi Takashi,
Chiu PoWen,
Lien ChenHsin,
Wu WenWei,
Lin ShuPing,
Li Wenwu,
Lin YenFu,
Chu Junhao
Publication year - 2021
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202005182
Subject(s) - neuroscience , materials science , neuroplasticity , synaptic plasticity , human brain , emulation , modulation (music) , optoelectronics , biology , psychology , physics , receptor , acoustics , social psychology , biochemistry
The human brain is often likened to an incredibly complex and intricate computer, rather than electrical devices, consisting of billions of neuronal cells connected by synapses. Different brain circuits are responsible for coordinating and performing specific functions. The reward pathway of the synaptic plasticity in the brain is strongly related to the features of both drug addiction and relief. In the current study, a synaptic device based on layered hafnium disulfide (HfS 2 ) is developed for the first time, to emulate the behavioral mechanisms of drug dosage modulation for neuroplasticity. A strong gate‐dependent persistent photocurrent is observed, arising from the modulation of substrate‐trapping events. By controlling the polarity of gate voltage, the basic functions of biological synapses are realized under a range of light spiking conditions. Furthermore, under the control of detrapping/trapping events at the HfS 2 /SiO 2 interface, positive/negative correlations of the A n / A 1 index, which significantly reflected the weight change of synaptic plasticity, are realized under the same stimulation conditions for the emulation of the drug‐related addition/relief behaviors in the brain. The findings provide a new advance for mimicking human brain plasticity.