Premium
Gallium–Carbenicillin Framework Coated Defect‐Rich Hollow TiO 2 as a Photocatalyzed Oxidative Stress Amplifier against Complex Infections
Author(s) -
Yang Jingjing,
Wang Chao,
Liu Xinli,
Yin Yi,
Ma YongHao,
Gao Yanfeng,
Wang Yuzhen,
Lu Zhenda,
Song Yujun
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202004861
Subject(s) - reactive oxygen species , materials science , antimicrobial , gallium , oxidative stress , microbiology and biotechnology , catalase , antibacterial activity , pseudomonas aeruginosa , bacteria , chemistry , biology , biochemistry , genetics , metallurgy
Abstract Development of new strategies with high antimicrobial capability against complex bacterial infections is still challenging. Herein, a three‐in‐one synergistic antimicrobial platform is presented based on gallium–carbenicillin framework coated defect‐rich hollow TiO 2 nanoshells (H‐TiO 2− x @MOF), for simultaneous eradicating methicillin‐resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA) in complex infections, which are the two most common bacteria in wounds. The metal gallium can disrupt bacterial antioxidation system using a “Trojan horse” strategy by substituting iron in the antioxidant enzymes, and finally increase bacterial susceptibility to oxidants. Meanwhile, oxygen‐deficient hollow TiO 2− x nanoshells (H‐TiO 2− x NSs) can efficiently bind to the bacteria and promote local generation of abundant reactive oxygen species (ROS) under visible‐light irradiation. Thus, the combination of gallium (antioxidant enzyme inhibitor) and black H‐TiO 2− x NSs (ROS generator) constitutes a photocatalyzed oxidative stress amplifier that can boost ROS accumulation to destroy pathogens thoroughly. In addition, carbenicillin (Car), as the organic ligand coordinated to gallium ion, also acts as a broad‐spectrum antibacterial agent against PA and shares the responsibility for combating complex infections simultaneously. In view of the superior antibacterial ability, accelerated healing of infected wounds, and good biosafety, the H‐TiO 2− x @MOF potentially provides an alternative antibacterial agent to combat complex bacterial infections.