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Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe 3 O 4 Magnetic Nanoparticles for Peripheral Nerve Regeneration
Author(s) -
Chen Xuan,
Ge Xuemei,
Qian Yun,
Tang Haozheng,
Song Jialin,
Qu Xinhua,
Yue Bing,
Yuan WeiEn
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202004537
Subject(s) - regeneration (biology) , materials science , sciatic nerve , scaffold , peripheral nerve injury , in vivo , electrospinning , biocompatibility , biomedical engineering , nanotechnology , anatomy , medicine , composite material , polymer , microbiology and biotechnology , biology , metallurgy
Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a promising scaffold for peripheral nerve repair, and bioactive agents are applied for great functional recovery. Melatonin (MLT) and Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 ‐MNPs) are proven to inhibit oxidative stress, inflammation, and induce nerve regeneration. Herein, a multilayered composite NGC loaded with MLT and Fe 3 O 4 ‐MNPs is designed for sequential and sustainable drug release, creating an appropriate microenvironment for nerve regeneration. The composite scaffold shows sufficient mechanical strength and biocompatibility in vitro, and evidently promotes morphological, functional, and electrophysiological recovery of regenerated sciatic nerves in vivo. This work proves that the multilayered conduits show great prospect in the long‐term nerve defects treatment due to easy manufacture and desired efficacy.