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Nanoengineered Light‐Activatable Polybubbles for On‐Demand Therapeutic Delivery
Author(s) -
Arun Kumar Shreedevi,
Good Jacob,
Hendrix David,
Yoo Eunsoo,
Kim Dongin,
Deo Kaivalya A.,
Jhan YongYu,
Gaharwar Akhilesh K.,
Bishop Corey J.
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202003579
Subject(s) - materials science , in vivo , on demand , nanorod , in vitro , nanotechnology , ex vivo , small molecule , chemistry , biochemistry , biology , computer science , microbiology and biotechnology , multimedia
Vaccine coverage is severely limited in developing countries due to inefficient protection of vaccine functionality as well as lack of patient compliance to receive the additional booster doses. Thus, there is an urgent need to design a thermostable vaccine delivery platform that also enables release of the bolus after predetermined time. Here, the formation of injectable and light‐activatable polybubbles for vaccine delivery is reported. In vitro studies show that polybubbles enable delayed burst release, irrespective of cargo types, namely small molecule and antigen. The extracorporeal activation of polybubbles is achieved by incorporating near‐infrared (NIR)‐sensitive gold nanorods (AuNRs). Interestingly, light‐activatable polybubbles can be used for on‐demand burst release of cargo. In vitro, ex vivo, and in vivo studies demonstrate successful activation of AuNR‐loaded polybubbles. Overall, the light‐activatable polybubble technology can be used for on‐demand delivery of various therapeutics including small molecule drugs, immunologically relevant protein, peptide antigens, and nucleic acids.