Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity | Zendy

Davenport Huyer Locke | Zendy; Mandla Serena | Zendy; Wang Yufeng | Zendy; Campbell Scott B. | Zendy; Yee Bess | Zendy; Euler Christian | Zendy; Lai Benjamin F. | Zendy; Bannerman A. Dawn | Zendy; Lin Dawn S. Y. | Zendy; Montgomery Miles | Zendy; Nemr Kayla | Zendy; Bender Timothy | Zendy; Epelman Slava | Zendy; Mahadevan Radhakrishnan | Zendy; Radisic Milica | Zendy

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Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity

Author(s) -

Davenport Huyer Locke,

Mandla Serena,

Wang Yufeng,

Campbell Scott B.,

Yee Bess,

Euler Christian,

Lai Benjamin F.,

Bannerman A. Dawn,

Lin Dawn S. Y.,

Montgomery Miles,

Nemr Kayla,

Bender Timothy,

Epelman Slava,

Mahadevan Radhakrishnan,

Radisic Milica

Publication year - 2021

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.202003341

Subject(s) - innate immune system , materials science , in vivo , biomaterial , polymer , macrophage polarization , polyester , macrophage , inflammation , in vitro , nanotechnology , immune system , chemistry , biology , immunology , biochemistry , composite material , microbiology and biotechnology

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer‐released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA.

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