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Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling
Author(s) -
Moon Junsang,
Christiansen Michael G.,
Rao Siyuan,
Marcus Colin,
Bono David C.,
Rosenfeld Dekel,
Gregurec Danijela,
Varnavides Georgios,
Chiang PoHan,
Park Seongjun,
Anikeeva Polina
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202000577
Subject(s) - multiplexing , materials science , magnetic nanoparticles , magnetic hyperthermia , dissipation , nanotechnology , magnet , coercivity , nanoparticle , magnetic field , heat generation , electronic engineering , electrical engineering , condensed matter physics , physics , engineering , thermodynamics , quantum mechanics
Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.