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Antifungal‐Inbuilt Metal–Organic‐Frameworks Eradicate Candida albicans Biofilms
Author(s) -
Su Linzhu,
Li Yuanfeng,
Liu Yong,
Ma Rujiang,
Liu Yang,
Huang Fan,
An Yingli,
Ren Yijin,
Mei Henny C.,
Busscher Henk J.,
Shi Linqi
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202000537
Subject(s) - voriconazole , candida albicans , biofilm , microbiology and biotechnology , antifungal , corpus albicans , chemistry , materials science , biology , bacteria , genetics
Fungal biofilms cause a major clinical problem with a shrinking armamentarium for treatment. Here, the design and synthesis of voriconazole‐inbuilt zinc 2‐methylimidazolates frameworks (V‐ZIF) is reported. Voriconazole is built in through coordination‐binding between zinc and voriconazole. These metal–organic‐frameworks with inbuilt voriconazole, reduce inadvertent voriconazole‐leakage, yield a zero‐order release kinetics of voriconazole, aid antifungal penetration in Candida albicans biofilms, and prevent Candida aggregation yielding better dispersal. Once accumulated in an acidic C. albicans biofilm, voriconazole dissociates from the metal–organic framework to cause membrane‐damage and killing of inhabiting fungi. Moreover, in a murine model, the V‐ZIFs eradicate open‐wound infections caused by C. albicans better than voriconazole in solution, with negligible side effects to the healthy tissues of major organs. Thus, V‐ZIFs may provide a welcome addition to the antifungal armamentarium currently available for the treatment of fungal biofilms.