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Ag Nanoparticles Cluster with pH‐Triggered Reassembly in Targeting Antimicrobial Applications
Author(s) -
Xie Xianli,
Sun TianCi,
Xue Jingzhe,
Miao Zhaohua,
Yan Xu,
Fang WeiWei,
Li Qing,
Tang Rupei,
Lu Yang,
Tang Longxiang,
Zha Zhengbao,
He Tao
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202000511
Subject(s) - staphylococcus aureus , escherichia coli , minimum inhibitory concentration , antimicrobial , antibacterial activity , materials science , nanoparticle , microbiology and biotechnology , in vivo , silver nanoparticle , methicillin resistant staphylococcus aureus , nanotechnology , bacteria , chemistry , biology , biochemistry , genetics , gene
Antibacterial efficiency can be effectively improved by applying targeting antibacterial materials and strategies. Herein, the successful synthesis of uniform pH‐responsive Ag nanoparticle clusters (AgNCs) is demonstrated, which can collapse and reassemble into nonuniform Ag NPs upon exposure to the acidic microenvironment of bacterial infections. This pH triggered reassembly contributes greatly to the improved antibacterial activities of AgNCs against both methicillin‐resistant Staphylococcus aureus (MRSA) and Escherichia coli ( E. coli ). The minimum inhibitory concentration and minimum bactericidal concentration against MRSA are as low as 4 and 32 µg mL −1 (which are 8 and 32 µg mL −1 for E. coli ), respectively. In vivo skin wound healing experiments confirm AgNCs can serve as an effective wound dressing to accelerate the healing of MRSA infection. The development of responsive AgNCs offers new materials and strategies in targeting antibacterial applications.