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Engineering Cell‐Derived Matrices: From 3D Models to Advanced Personalized Therapies
Author(s) -
RubiSans Gerard,
Castaño Oscar,
Cano Irene,
MateosTimoneda Miguel A.,
PerezAmodio Soledad,
Engel Elisabeth
Publication year - 2020
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.202000496
Subject(s) - regeneration (biology) , regenerative medicine , tissue engineering , in vivo , extracellular matrix , computer science , biochemical engineering , materials science , cell , nanotechnology , computational biology , biomedical engineering , biology , microbiology and biotechnology , medicine , engineering , biochemistry
Regenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell‐derived matrices (CDMs) have emerged as new modifiable extracellular matrices for a variety of tissues, allowing researchers to study basic cellular processes in tissue‐like structures, test tissue regeneration approaches, and model disease development. In this review, different fabrication techniques and characterization methods of CDMs are presented and examples of their application in cell behavior studies, tissue regeneration, and disease models are provided. In addition, future guidelines and perspectives in the field of CDMs are discussed.